such-4

Caenorhabditis elegans

abf-4

Caenorhabditis elegans

Is affected by several genes including cyc-1; hyl-2; and swsn-9 based on microarray; tiling array; and RNA-seq studies. Is affected by six chemicals including Cadmium Chloride; bortezomib; and resveratrol based on RNA-seq and microarray studies.

abt-4

Caenorhabditis elegans

Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in intracellular membrane-bounded organelle. Expressed in head and tail. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Is an ortholog of human ABCA3 (ATP binding cassette subfamily A member 3).

acbp-4

Caenorhabditis elegans

Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in cytoplasm. Expressed in intestine.

alh-4

Caenorhabditis elegans

Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to be located in cytoplasm. Expressed in hypodermis. Used to study Sjogren-Larsson syndrome. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Is an ortholog of human ALDH3A1 (aldehyde dehydrogenase 3 family member A1); ALDH3A2 (aldehyde dehydrogenase 3 family member A2); and ALDH3B1 (aldehyde dehydrogenase 3 family member B1).

aqp-4

Caenorhabditis elegans

Enables water channel activity. Involved in water transport. Located in apical plasma membrane. Expressed in intestine. Is an ortholog of human AQP8 (aquaporin 8).

asp-4

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Is an ortholog of human CTSD (cathepsin D).

bath-4

Caenorhabditis elegans

Enriched in ABalaapppa; ABalapaapa; germ line; germline precursor cell; and head mesodermal cell based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including cyc-1; mut-2; and nuo-6 based on microarray and RNA-seq studies. Is affected by fourteen chemicals including rotenone; stavudine; and Zidovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: MATH domain; MATH/TRAF domain; BTB and MATH domain-containing protein; BTB/POZ domain; TRAF-like; and SKP1/BTB/POZ domain superfamily.

best-4

Caenorhabditis elegans

Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy and retinal degeneration (multiple). Is an ortholog of human BEST1 (bestrophin 1) and BEST3 (bestrophin 3).

btb-4

Caenorhabditis elegans

Enriched in AFD; AVE; body wall muscle cell; germ line; and germline precursor cell based on tiling array and RNA-seq studies. Is affected by several genes including nuo-6; etr-1; and hsf-1 based on microarray and RNA-seq studies. Is affected by nine chemicals including rotenone; Psoralens; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: SKP1/BTB/POZ domain superfamily and BTB/POZ domain.