acl-12

Caenorhabditis elegans

Predicted to enable acyltransferase activity. Involved in IRE1-mediated unfolded protein response and PERK-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum.

acr-12

Caenorhabditis elegans

Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in calcium ion import across plasma membrane and regulation of muscle contraction. Located in synapse. Expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).

btb-12

Caenorhabditis elegans

Enriched in ALA; germ line; and muscle cell based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including swsn-1; puf-8; and etr-1 based on microarray and RNA-seq studies. Is affected by seven chemicals including stavudine; rifampin; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: SKP1/BTB/POZ domain superfamily and BTB/POZ domain.

bus-12

Caenorhabditis elegans

Predicted to enable antiporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in Golgi apparatus. Expressed in intestine and seam cell. Is an ortholog of human SLC35D3 (solute carrier family 35 member D3).

dmsr-12

Caenorhabditis elegans

Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Expressed in CEMDL and CEMDR.

egl-12

Caenorhabditis elegans

hlh-12

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in gonad morphogenesis; positive regulation of distal tip cell migration; and positive regulation of gene expression. Located in nucleus. Expressed in anterior distal tip cell; distal tip cell; linker cell; and posterior distal tip cell. Is an ortholog of human FERD3L (Fer3 like bHLH transcription factor).

hpo-12

Caenorhabditis elegans

Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in thiamine pyrophosphate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Is an ortholog of human SLC25A19 (solute carrier family 25 member 19).

ins-12

Caenorhabditis elegans

Expressed in head neurons; motor neurons; nerve ring neurons; rectum; and sensory neurons.

mvb-12

Caenorhabditis elegans

Predicted to enable SH3 domain binding activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway and receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Expressed in amphid neurons; hypodermis; intestine; and pm7. Is an ortholog of human MVB12B (multivesicular body subunit 12B).