ama-1

Caenorhabditis elegans

Contributes to RNA polymerase II activity. Involved in embryo development; gastrulation; and mRNA transcription by RNA polymerase II. Located in chromosome and nuclear body. Part of euchromatin. Is an ortholog of human POLR2A (RNA polymerase II subunit A).

cit-1.2

Caenorhabditis elegans

Enables cyclin-dependent protein serine/threonine kinase activator activity. Involved in embryo development. Located in nucleus. Expressed in several structures, including head. Is an ortholog of human CCNT1 (cyclin T1).

wwp-1

Caenorhabditis elegans

Enables ubiquitin conjugating enzyme activity. Involved in defense response to bacterium; protein ubiquitination; and regulation of protein catabolic process. Acts upstream of or within determination of adult lifespan. Located in cytoplasm. Expressed in GABAergic neurons; cholinergic neurons; coelomocyte; somatic neurons; and vulval muscle. Is an ortholog of human WWP1 (WW domain containing E3 ubiquitin protein ligase 1) and WWP2 (WW domain containing E3 ubiquitin protein ligase 2).

cit-1.1

Caenorhabditis elegans

Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of DNA-templated transcription, elongation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Expressed widely. Is an ortholog of human CCNT1 (cyclin T1).

taf-4

Caenorhabditis elegans

Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in several processes, including determination of adult lifespan; regulation of mitotic cell cycle, embryonic; and transcription initiation at RNA polymerase II promoter. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and spermatogenic failure 13. Is an ortholog of human TAF4B (TATA-box binding protein associated factor 4b).

xpa-1

Caenorhabditis elegans

Predicted to enable damaged DNA binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and response to UV-C. Located in nucleus. Human ortholog(s) of this gene implicated in xeroderma pigmentosum group A. Is an ortholog of human XPA (XPA, DNA damage recognition and repair factor).