Enables DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of locomotion and response to xenobiotic stimulus. Predicted to be located in nucleus. Predicted to be part of nuclear aryl hydrocarbon receptor complex. Expressed in ALML; ALMR; RMEL; RMER; and neurons. Human ortholog(s) of this gene implicated in pancreatic cancer and retinitis pigmentosa 85. Is an ortholog of human AHR (aryl hydrocarbon receptor).
Is affected by several genes including mrps-5; ahr-1; and egl-9 based on RNA-seq studies. Is affected by silicon dioxide nanoparticle based on microarray studies.
Predicted to enable guanylate cyclase activity. Involved in chemosensory behavior and sensory perception of bitter taste. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)).
Enables DNA binding activity; DNA-binding transcription factor activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of transcription by RNA polymerase II; and social behavior. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in hypodermis; intestine; neurons; and pharynx. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in renal cell carcinoma and type 2 diabetes mellitus. Is an ortholog of human ARNT (aryl hydrocarbon receptor nuclear translocator) and ARNT2 (aryl hydrocarbon receptor nuclear translocator 2).
Enables oxygen sensor activity and small molecule binding activity. Involved in aerotaxis; cGMP-mediated signaling; and response to stress. Located in dendrite and neuronal cell body. Expressed in body wall musculature and pharyngeal muscle cell. Is an ortholog of human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)).