ace-1

Caenorhabditis elegans

Enables acetylcholinesterase activity and identical protein binding activity. Involved in acetylcholine catabolic process and regulation of locomotion. Located in extracellular space. Expressed in CEP; M cell; OLL; body wall musculature; and non-striated muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); and autoimmune disease (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase).

ace-3

Caenorhabditis elegans

Enables acetylcholinesterase activity and protein homodimerization activity. Involved in several processes, including acetylcholine catabolic process; hatching; and regulation of backward locomotion. Predicted to be located in extracellular space and plasma membrane. Expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); and autoimmune disease (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase).

Y116A8C.30

Caenorhabditis elegans

Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 10. Is an ortholog of human NDUFAF2 (NADH:ubiquinone oxidoreductase complex assembly factor 2).

mars-2

Caenorhabditis elegans

rpac-19

Caenorhabditis elegans

Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III and transcription elongation by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Used to study obesity. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Is an ortholog of human POLR1D (RNA polymerase I and III subunit D).

seg-2

Caenorhabditis elegans

nduv-2

Caenorhabditis elegans

Predicted to enable 2 iron, 2 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Is an ortholog of human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2).

nduo-2

Caenorhabditis elegans

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I.

tif-1A

Caenorhabditis elegans

Predicted to enable RNA polymerase I core binding activity and RNA polymerase I general transcription initiation factor activity. Predicted to be involved in transcription initiation at RNA polymerase I promoter. Predicted to be located in nucleus. Is an ortholog of human RRN3 (RRN3 homolog, RNA polymerase I transcription factor).

rpoa-49

Caenorhabditis elegans

Predicted to enable DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and transcription elongation by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be part of RNA polymerase I complex. Is an ortholog of human POLR1E (RNA polymerase I subunit E).