- jun-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Expressed in several structures, including excretory cell; hermaphrodite gonad; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and lymphoma (multiple). Is an ortholog of human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit).
- sek-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable JUN kinase kinase activity. Predicted to be involved in MAPK cascade. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K4 (mitogen-activated protein kinase kinase 4).
- Jra [Search on AGR]
Drosophila melanogaster Jun-related antigen (Jra) encodes a homologue of the mammalian transcription factor Jun and has pleiotropic roles in the CNS. Jra activity is regulated by many upstream enzymes, including bsk.
- Ppp4r1 [Search on AGR]
Homo sapiens This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
- Dnah7 [Search on AGR]
Homo sapiens DNAH7 is a component of the inner dynein arm of ciliary axonemes (Zhang et al., 2002 [PubMed 11877439]).[supplied by OMIM, Mar 2008]
- Map3k21 [Search on AGR]
Rattus norvegicus Predicted to enable JUN kinase kinase kinase activity. Predicted to be involved in MAPK cascade. Orthologous to human MAP3K21 (mitogen-activated protein kinase kinase kinase 21); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH alpha-Zearalanol; bisphenol A; methoxychlor.