- ogdh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in protein folding. Located in mitochondrion. Expressed in head and tail. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Is an ortholog of human OGDH (oxoglutarate dehydrogenase).
- Slc16a8 [Search on AGR]
Homo sapiens SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
- Hk [Search on AGR]
Drosophila melanogaster Hyperkinetic (Hk) encodes a beta-subunit of Sh K[+] channels and modulates its channel function. It is important in regulating action potentials in neurons and muscles, and transmitter release.
- atad-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in mitochondrion organization. Located in mitochondrion. Human ortholog(s) of this gene implicated in Harel-Yoon syndrome and neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome. Is an ortholog of human ATAD3A (ATPase family AAA domain containing 3A) and ATAD3B (ATPase family AAA domain containing 3B).
- Shab [Search on AGR]
Drosophila melanogaster Shaker cognate b (Shab) encodes a member of the Sh family and the structural alpha subunit of a delayed rectifier K[+] channel (Kv2). The product of Shab channel functions to regulate excitability in neurons and muscles, and transmitter release.
- Sh [Search on AGR]
Drosophila melanogaster Shaker (Sh) encodes the structural alpha subunit of a voltage-gated potassium channel. It plays a key role in maintaining electrical excitability in neurons and muscle cells, as well as regulating neurotransmitter release at the synapse.
- qvr [Search on AGR]
Drosophila melanogaster quiver (qvr) encodes a Ly-6 protein. Ly-6 proteins are GPI-linked or secreted proteins that modulate the trafficking and/or activity of membrane protein targets, including the potassium channel encoded by Sh and nicotinic acetylcholine receptors.
- ced-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables clathrin adaptor activity and scavenger receptor binding activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and positive regulation of distal tip cell migration. Located in cytoplasmic side of plasma membrane and phagocytic vesicle. Is an ortholog of human GULP1 (GULP PTB domain containing engulfment adaptor 1).
- Ogdhl [Search on AGR]
Rattus norvegicus Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome. Orthologous to human OGDHL (oxoglutarate dehydrogenase L); PARTICIPATES IN citric acid cycle pathway; lysine degradation pathway; tryptophan metabolic pathway; INTERACTS WITH acetamide; aflatoxin B1; bisphenol A.
- ced-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Involved in several processes, including engulfment of apoptotic cell; positive regulation of distal tip cell migration; and positive regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); chronic myeloid leukemia; and invasive ductal carcinoma. Is an ortholog of human CRK (CRK proto-oncogene, adaptor protein) and CRKL (CRK like proto-oncogene, adaptor protein).