- Npy6r [Search on AGR]
Homo sapiens Predicted to enable pancreatic polypeptide receptor activity and peptide YY receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
- Pyy [Search on AGR]
Rattus norvegicus Predicted to enable neuropeptide Y receptor binding activity and neuropeptide hormone activity. Involved in negative regulation of response to food. Located in extracellular space. Orthologous to several human genes including PYY (peptide YY); INTERACTS WITH aldehydo-D-glucose; ammonium chloride; bisphenol A.
- gex-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA 7-methylguanosine cap binding activity. Involved in several processes, including embryonic body morphogenesis; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in cell junction. Part of SCAR complex. Human ortholog(s) of this gene implicated in several diseases, including Schaaf-Yang syndrome; autism spectrum disorder; and epilepsy (multiple). Is an ortholog of human CYFIP1 (cytoplasmic FMR1 interacting protein 1) and CYFIP2 (cytoplasmic FMR1 interacting protein 2).
- Npy1r [Search on AGR]
Homo sapiens This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
- Npy5r [Search on AGR]
Homo sapiens The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
- Npy2r [Search on AGR]
Rattus norvegicus Enables peptide YY receptor activity. Involved in several processes, including negative regulation of cell communication; regulation of nervous system process; and regulation of secretion. Predicted to be located in non-motile cilium. Predicted to be active in cilium. Used to study childhood absence epilepsy and depressive disorder. Biomarker of obesity. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (neuropeptide Y receptor Y2); INTERACTS WITH 1D-myo-inositol 1,4,5-trisphosphate; ammonium chloride; bisphenol A.
- Npy5r [Search on AGR]
Rattus norvegicus Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including generation of ovulation cycle rhythm; negative regulation of GABAergic synaptic transmission; and regulation of acute inflammatory response. Predicted to be located in membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; neuron projection; and presynapse. Used to study childhood absence epilepsy; hyperinsulinism; and visual epilepsy. Biomarker of coronary restenosis; obesity; and prolactinoma. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitriptyline.
- Magel2 [Search on AGR]
Rattus norvegicus Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; protein K63-linked ubiquitination; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within positive regulation of actin nucleation. Predicted to be located in endosome. Predicted to be part of retromer complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Orthologous to human MAGEL2 (MAGE family member L2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
- Npy1r [Search on AGR]
Rattus norvegicus Predicted to enable neuropeptide binding activity; pancreatic polypeptide receptor activity; and peptide YY receptor activity. Involved in several processes, including positive regulation of cholesterol biosynthetic process; regulation of presynaptic cytosolic calcium ion concentration; and regulation of secretion by cell. Located in axon and synaptic vesicle. Is active in glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Used to study anxiety disorder; childhood absence epilepsy; depressive disorder; and hypertension. Biomarker of obesity and visual epilepsy. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1); INTERACTS WITH 17beta-estradiol; 1D-myo-inositol 1,4,5-trisphosphate; 2,3,7,8-tetrachlorodibenzodioxine.