Sp2

Homo sapiens

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

Sp7

Homo sapiens

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]

gex-2

Caenorhabditis elegans

Predicted to enable RNA 7-methylguanosine cap binding activity. Involved in several processes, including embryonic body morphogenesis; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in cell junction. Part of SCAR complex. Human ortholog(s) of this gene implicated in several diseases, including Schaaf-Yang syndrome; autism spectrum disorder; and epilepsy (multiple). Is an ortholog of human CYFIP1 (cytoplasmic FMR1 interacting protein 1) and CYFIP2 (cytoplasmic FMR1 interacting protein 2).

Lck

Mus musculus

PHENOTYPE: Mice homozygous for mutations of this gene exhibit thymic atrophy with reduced numbers of peripheral T cells. Null mutants have few double positive and no mature single positive (SP) thymocytes. A hypomorph has decreased expression of CD3epsilon chain on SP thymocytes, whose numbers are reduced. [provided by MGI curators]

Sp1

Drosophila melanogaster

Sp1 (Sp1) encodes a member of the Sp-family of Cys2His2-type zinc finger transcription factors. It is involved in ventral thoracic appendage specification, leg growth and in the development of type-II neuroblasts.

tlp-1

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including body wall musculature; rectal valve cell; somatic nervous system; tail precursor cell; and tail spike. Is an ortholog of human ZNF503 (zinc finger protein 503) and ZNF703 (zinc finger protein 703).

Sp8

Homo sapiens

The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

CG17575

Drosophila melanogaster

CG17575 encodes a cysteine-rich secretory protein produced in the male accessory glands and transferred to females during mating. In mated females, it is required for the binding of the product of SP to sperm and for the consequent maintenance of long-term post-mating responses.

aqrs

Drosophila melanogaster

aquarius (aqrs) encodes a predicted serine protease produced by the male accessory glands and transferred to females during mating. It is required for the binding of the product of SP to sperm and for the transfer of the products of lectin-46Ca and lectin-46Cb to females during mating.

lectin-46Cb

Drosophila melanogaster

lectin-46Cb (lectin-46Cb) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, is required for the binding of product of SP to sperm, and for maintenance of long-term post-mating responses.