bac-1

Caenorhabditis elegans

zmp-1

Caenorhabditis elegans

Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Is an ortholog of human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24).

aff-1

Caenorhabditis elegans

Involved in regulation of egg-laying behavior and syncytium formation by plasma membrane fusion. Located in plasma membrane. Expressed in anchor cell; egg-laying apparatus; epithelial cell; neurons; and pharyngeal muscle cell.

cdh-3

Caenorhabditis elegans

Predicted to enable structural molecule activity. Involved in basement membrane disassembly and nematode male tail tip morphogenesis. Located in basement membrane; cytoplasm; and plasma membrane. Expressed in several structures, including HSN; VC neuron; anchor cell; epithelial cell; and ventral nerve cord.

Aca71

Mus musculus

PHENOTYPE: Visualization with the Zeiss AC-Master reveals that lenses of mice with this mutation are smaller than normal. [provided by MGI curators]

hlh-2

Caenorhabditis elegans

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein dimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; regulation of metabolic process; and sex differentiation. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including distal tip cell; enteric muscle; lateral ganglion; ray precursor cell; and terminal bulb. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including Fuchs' endothelial dystrophy; Pitt-Hopkins syndrome; and agammaglobulinemia (multiple). Is an ortholog of human TCF12 (transcription factor 12); TCF3 (transcription factor 3); and TCF4 (transcription factor 4).

unc-6

Caenorhabditis elegans

Predicted to enable signaling receptor binding activity. Involved in several processes, including axon guidance; regulation of locomotion; and sex differentiation. Acts upstream of or within dendrite morphogenesis. Located in axon; basement membrane; and cytoplasm. Expressed in several structures, including P1; VA12; accessory cell; interneuron; and somatic neurons. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Is an ortholog of human NTN1 (netrin 1).

ac

Drosophila melanogaster

achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.

Y47G6A.19

Caenorhabditis elegans

Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis.

chn

Drosophila melanogaster

charlatan (chn) encodes a C2H2 zinc-finger transcriptional factor that regulates multiple genes, including emc, hry, ac and Delta. It functions in sensory neurons, photoreceptors, blood cells, muscle precursors and intestinal precursors.