pk

Drosophila melanogaster

prickle (pk) encodes a core component of the Frizzled-dependent planar polarity complex, which localises to cell junctions in developing epithelia, most likely via direct protein-protein interactions with the transmembrane proteins encoded by Vang and stan. pk product contributes to planar polarity defects in epithelia, as well as nervous system development.

capa-1

Caenorhabditis elegans

Enables G protein-coupled receptor binding activity. Involved in neuropeptide signaling pathway. Expressed in ASGL and ASGR.

nmur-2

Caenorhabditis elegans

Enables neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Predicted to be located in plasma membrane. Is an ortholog of human NMUR1 (neuromedin U receptor 1) and NMUR2 (neuromedin U receptor 2).

dachs

Drosophila melanogaster

dachs (dachs) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts.

Prkdc

Homo sapiens

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]

Lig4

Homo sapiens

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Mcm4

Homo sapiens

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]