Unc13b

Mus musculus

PHENOTYPE: Homozygous mutant mice are grossly phenotypically normal. Mice older than 12 months will exhibit sporadic seizures. [provided by MGI curators]

Rgsc431

Mus musculus

PHENOTYPE: Mice with a mutation of this gene exhibit kinking, sometimes accompanied by shortening and thickening, of the tail; rarely, a mouse will present with no tail. [provided by MGI curators]

Bfo

Mus musculus

PHENOTYPE: Bfo, in certain strains, will cause a PMSG-injected females to release a larger number of ova in response to an intermittently ringing bell or flashing high-intensity light. [provided by MGI curators]

Psd2

Saccharomyces cerevisiae

Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected

pash-1

Caenorhabditis elegans

Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in primary miRNA processing and regulation of developmental process. Predicted to be part of microprocessor complex. Expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in alcohol dependence. Is an ortholog of human DGCR8 (DGCR8 microprocessor complex subunit).

Gng3

Homo sapiens

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]

Cbl

Drosophila melanogaster

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

Pis

Drosophila melanogaster

Phosphatidylinositol synthase (Pis) encodes an enzyme involved in the synthesis of phosphatidyl inositol, which is further modified to give rise to phosphorylated membrane lipids with multiple functions. It is important for membrane composition and Pis mutants develop various cellular polarity abnormalities, e.g. epithelial cells will misposition basement membrane proteins at their apical side, due to a lack of PIP2.

Dnm1

Saccharomyces cerevisiae

Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy

wda

Drosophila melanogaster

will decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5.