- RCR1 [Search on AGR]
Saccharomyces cerevisiae Plasma membrane (PM) ubiquitin ligase-substrate adaptor; involved in cell wall chitin deposition; ubiquitinates and down-regulates chitin synthase Chs3p abundance at PM via calcineurin/Crz1 signaling pathway which regulates RCR1 expression; delivered to PM by exomer complex using novel PM sorting motif; RCR1 has a paralog, RCR2, that arose from the whole genome duplication
- IST2 [Search on AGR]
Saccharomyces cerevisiae Cortical ER protein involved in ER-plasma membrane (PM) tethering; one of 6 proteins (Ist2, Scs2, Scs22, Tcb1, Tcb2, Tcb3) that connect ER to PM, regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1 phosphatase to PI4P; required to locate Osh6, Osh7 in ER/PM contact site to allow phosphatidylserine transport from ER to PM; localizes to mother in small-budded cells, to bud in medium-, large-budded cells; mRNA transported to bud tip by actomyosin-driven process
- Tmgc21 [Search on AGR]
Mus musculus PHENOTYPE: Mutant mice display white belly spotting with white feet. [provided by MGI curators]
- TSC11 [Search on AGR]
Saccharomyces cerevisiae Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; contains an N-terminal armadillo repeat region necessary for recruitment to the PM and for anchoring Tor2p and Avo1p at the PM; acts along with Avo1p as a scaffold important for integrity of the TORC2 complex; involved in sphingolipid metabolism; contains a RasGEFN domain
- Rgsc58 [Search on AGR]
Mus musculus PHENOTYPE: Mice with a mutation of this gene exhibit white banding, white spotting or scattered white hairs in the dorsal lumbar region. [provided by MGI curators]
- AVO2 [Search on AGR]
Saccharomyces cerevisiae Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p
- crn-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3'-5'-RNA exonuclease activity and single-stranded RNA binding activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Predicted to be located in nucleolus. Predicted to be part of nuclear exosome (RNase complex). Is an ortholog of human EXOSC10 (exosome component 10).
- fc [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mice have a white head spot and occassionally a white belly spot. [provided by MGI curators]
- CPP2 [Search on AGR]
Saccharomyces cerevisiae Tail-anchored plasma membrane (PM) protein; C-terminal palmitoylation is required for membrane anchoring and protein stability; PM localization is polarized to the daughter cell; contains a conserved cysteine rich palmitoylated domain (CYSPD, aka CYSTM); related proteins in other organisms may be involved in response to stress
- TCB1 [Search on AGR]
Saccharomyces cerevisiae Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of the Sac1p phosphatase to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER and to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact