- C7orf33 [Search on AGR]
Homo sapiens ASSOCIATED WITH cortical dysplasia-focal epilepsy syndrome; Weaver syndrome; INTERACTS WITH benzo[a]pyrene; folic acid
- TMUE_2000009859 [Browse genome (BioProject PRJEB126)] [Search on AGR]
Trichuris muris Is predicted to encode a protein with the following domains: Ubiquitin family; DC-UbP/UBTD2, N-terminal domain superfamily; Ubiquitin-binding domain; Ubiquitin-like domain superfamily; Ubiquitin-like domain; and DC-UbP/UBTD2, N-terminal domain.
- Tbxa2r [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for a null allele show prolonged bleeding, and altered platelet aggregation and vascular responses to TXA2, arachidonic acid and injury. Homozygotes for another null allele show splenomegaly, reduced DC-T cell adhesion, enhanced contact hypersensitivity, and cervical lymphadenopathy. [provided by MGI curators]
- Dcst2 [Search on AGR]
Rattus norvegicus Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization and sperm-egg recognition. Predicted to be located in membrane. Orthologous to human DCST2 (DC-STAMP domain containing 2); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
- Dcst1 [Search on AGR]
Rattus norvegicus Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including fusion of sperm to egg plasma membrane involved in single fertilization; negative regulation of type I interferon-mediated signaling pathway; and sperm-egg recognition. Predicted to be located in plasma membrane. Orthologous to human DCST1 (DC-STAMP domain containing 1); INTERACTS WITH 4,4'-diaminodiphenylmethane; aflatoxin B1; alpha-Zearalanol.
- Ezh2 [Search on AGR]
Rattus norvegicus Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including GABAergic synaptic transmission; negative regulation of macromolecule biosynthetic process; and positive regulation of dendrite development. Predicted to be located in chromosome, telomeric region; nucleoplasm; and pronucleus. Predicted to be part of ESC/E(Z) complex; chromatin silencing complex; and pericentric heterochromatin. Predicted to be active in chromosome and nucleus. Used to study endometriosis. Biomarker of leiomyoma; metabolic dysfunction-associated steatotic liver disease; and pancreatic cancer. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
- Nsd1 [Search on AGR]
Homo sapiens This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Sep 2018]