Transportin (Tnpo) encodes a protein involved in Hh signalling regulation by mediating the import of the transcription factor encoded by ci into the nucleus.
debra (dbr) encodes a transcriptional coactivator of various transcription factors, including the products of ci and dl. It contributes to developmental patterning, long-term memory, and cellular proliferation.
Suppressor of fused (Su(fu)) encodes a negative regulator of the Hedgehog signaling pathway. It forms a complex with the transcription factor encoded by ci to inhibit its activity.
hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways.
cubitus interruptus (ci) encodes a Zn-finger family of transcription factor. It contributes to Hedgehog (Hh) signaling pathway that is involved in pattern formation and growth control. The product of ci undergoes limited proteolysis to be converted into a truncated form that function as a transcription repressor in the absence of the ligand encoded by hh but is converted into a full-length transcription activator in the presence of the product of hh.
Is predicted to encode a protein with the following domains: Thioredoxin-like superfamily; Ribosomal protein/NADH dehydrogenase domain; and Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain. Is an ortholog of C. elegans T09A5.5.
Is predicted to encode a protein with the following domains: Thioredoxin-like superfamily; Ribosomal protein/NADH dehydrogenase domain; and Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain. Is an ortholog of C. elegans mrps-25.
Is predicted to encode a protein with the following domains: NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2; Ribosomal protein/NADH dehydrogenase domain; Thioredoxin-like superfamily; and Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain.