- K02F3.12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Predicted to be located in chromosome and cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Is an ortholog of human RECQL (RecQ like helicase).
- Sema4b [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a gene trap allele exhibit normal cerebellar morphology. Mice homozygous for a knock-out allele exhibit enhanced memory response by way of increased IgE and IgG1 serum levels. [provided by MGI curators]
- fng [Search on AGR]
Drosophila melanogaster fringe (fng) encodes a glycosyltransferase that modifies EGF domains of the product of N. This glycosylation enhances the interactions the product of N with its ligand encoded by Delta, and inhibits those with its ligand encoded by Ser. In this way the product of fng modulates Notch signaling.
- Cal6 [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for this spontaneous mutation exhibit a very curly coat and kinked vibrissae at 3 weeks of age. With age, the coat of mutant mice becomes straighter but appears to be rubbed the wrong way, while the vibrissae appear less kinked. [provided by MGI curators]
- Timm22 [Search on AGR]
Homo sapiens Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]
- fws [Search on AGR]
Drosophila melanogaster four way stop (fws) encodes a protein localised to the Golgi apparatus and involved in several aspects of spermatogenesis. Loss of function of fws causes failure of cleavage furrow ingression in dividing spermatocytes, as well as failure of cell elongation and disruption of the Golgi-based acroblast during spermatid differentiation
- atf-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in hydrogen sulfide biosynthetic process and positive regulation of gene expression. Located in nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4) and ATF5 (activating transcription factor 5).
- mlt-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in extracellular space. Expressed in hypodermis.