- ZFPM2-AS1 [Search on AGR]
Homo sapiens ASSOCIATED WITH 46,XY sex reversal 3; 46,XY sex reversal 9; Diaphragmatic Hernia 3; INTERACTS WITH aristolochic acid A; cadmium dichloride; Didecyldimethylammonium
- Rsxr [Search on AGR]
Mus musculus PHENOTYPE: The Rsxr<sup>129S1/Sv</sup> allele confers resistance to sex reversal in genetic XY males from consomic line B6.129-Chr Y<sup>POS</sup>. The Rsxr<sup>C57BL/6J</sup> allele confers sex reversal in genetic XY males from consomic line C57BL/6J-Hba<sup>th-J</sup> Chr Y<sup>POS</sup>. [provided by MGI curators]
- Chd7 [Search on AGR]
Homo sapiens ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); ATP-dependent chromatin remodeler activity (inferred); INVOLVED IN central nervous system development; cognition; cranial nerve development; PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIATED WITH 3MC syndrome; 46, XY Disorders of Sex Development; 46,XY sex reversal; FOUND IN nucleolus; nucleoplasm; nucleus; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one
- Sry [Search on AGR]
Mus musculus PHENOTYPE: Variations in expression of alleles on specific backgrounds result in partial and/or complete male to female sex reversal. Deletion of alleles results in XY females. [provided by MGI curators]
- Sry [Search on AGR]
Rattus norvegicus Enables enzyme binding activity and sequence-specific DNA binding activity. Involved in male sex determination and positive regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in 46,XX sex reversal 1; 46,XY sex reversal; and 46,XY sex reversal 1. Orthologous to human SRY (sex determining region Y); INTERACTS WITH ammonium chloride; bisphenol A; copper atom.
- t [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mice die during embryonic development. Heterozygous mice have skeletal abnormalities. On specific genetic backgrounds, some alleles cause partial or complete sex-reversal of chromosomally XY mice. [provided by MGI curators]
- Caps2 [Search on AGR]
Homo sapiens Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar 2008]
- Dhh [Search on AGR]
Rattus norvegicus Predicted to enable calcium ion binding activity; patched binding activity; and zinc ion binding activity. Involved in several processes, including response to estradiol; response to estrogen; and spermatid development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in 46,XY sex reversal and 46,XY sex reversal 7. Orthologous to human DHH (desert hedgehog signaling molecule); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3-bis(4-hydroxyphenyl)propionitrile.
- Rad51ap2 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a truncated allele exhibit decreased testis weight, oligospermia, arrested male meiosis, and abnormal increased frequency of XY dissociation in meiotic metaphase I spermatocytes with reduced crossover and compromised double-strand break repair in the pseudoautosomal region. [provided by MGI curators]
- rha-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity and helicase activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Is an ortholog of human DHX37 (DEAH-box helicase 37).