apg-1

Caenorhabditis elegans

Predicted to enable clathrin adaptor activity and clathrin binding activity. Involved in apical protein localization and protein secretion. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of AP-1 adaptor complex. Is an ortholog of human AP1G1 (adaptor related protein complex 1 subunit gamma 1).

apd-3

Caenorhabditis elegans

Predicted to be involved in intracellular transport and synaptic vesicle membrane organization. Predicted to be located in endosome membrane; presynaptic endosome; and terminal bouton. Predicted to be part of AP-3 adaptor complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Is an ortholog of human AP3D1 (adaptor related protein complex 3 subunit delta 1).

sdz-12

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Expressed in several structures, including Z4.ap; dorsal uterine precursor; head muscle; head neurons; and ventral uterine precursor. Is an ortholog of human ZNF501 (zinc finger protein 501).

aps-1

Caenorhabditis elegans

Involved in apical protein localization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of AP-1 adaptor complex. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Is an ortholog of human AP1S1 (adaptor related protein complex 1 subunit sigma 1) and AP1S2 (adaptor related protein complex 1 subunit sigma 2).

Y45G5AM.9

Caenorhabditis elegans

Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be located in trans-Golgi network membrane. Predicted to be part of AP-1 adaptor complex. Is an ortholog of human AFTPH (aftiphilin).

APS1

Saccharomyces cerevisiae

Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex

ndx-4

Caenorhabditis elegans

Enables 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity and bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Involved in nucleotide metabolic process. Is an ortholog of human NUDT2 (nudix hydrolase 2).

APS2

Saccharomyces cerevisiae

Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex

APM4

Saccharomyces cerevisiae

Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals

apb-3

Caenorhabditis elegans

Involved in embryo development and lysosome organization. Predicted to be located in clathrin-coated vesicle membrane. Predicted to be part of AP-3 adaptor complex. Expressed in motor neurons. Human ortholog(s) of this gene implicated in several diseases, including Hermansky-Pudlak syndrome 2; developmental and epileptic encephalopathy 48; and pulmonary fibrosis. Is an ortholog of human AP3B2 (adaptor related protein complex 3 subunit beta 2).