tufm-2

Caenorhabditis elegans

Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in mitochondrion.

cpz-2

Caenorhabditis elegans

Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in extracellular space. Is an ortholog of human CTSZ (cathepsin Z).

tufm-1

Caenorhabditis elegans

Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Is an ortholog of human TUFM (Tu translation elongation factor, mitochondrial).

cap-1

Caenorhabditis elegans

Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Part of dynactin complex. Expressed in rectal valve cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in male infertility. Is an ortholog of human CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) and CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2).

ZK1321.4

Caenorhabditis elegans

Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization and muscle structure development. Predicted to be located in Z disc; adherens junction; and stress fiber. Predicted to be part of filamentous actin.

TUF1

Saccharomyces cerevisiae

Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria

rba-1

Caenorhabditis elegans

Predicted to enable histone binding activity. Involved in cell fate specification; nematode male tail tip morphogenesis; and regulation of neurogenesis. Predicted to be located in nucleus. Predicted to be part of ESC/E(Z) complex and NuRD complex. Is an ortholog of human RBBP7 (RB binding protein 7, chromatin remodeling factor).

cpz-1

Caenorhabditis elegans

Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; gonad morphogenesis; and post-embryonic development. Located in collagen and cuticulin-based cuticle extracellular matrix; extracellular space; and yolk granule. Expressed in several structures, including anterior hypodermis; cuticle; intestine; pharynx; and vulva. Is an ortholog of human CTSZ (cathepsin Z).

Su(z)12

Drosophila melanogaster

Su(z)12 (Su(z)12) is a member of the Polycomb group of genes with products involved in transcriptional silencing. Su(z)12 encodes a subunit of Polycomb repressive complex 2 (PRC2), where it is required for the histone methyltransferase activity that yields trimethylation of histone H3 on lysine 27 (H3-K27me3).

Su(z)2

Drosophila melanogaster

Suppressor of zeste 2 (Su(z)2) encodes a protein that regulates gene expression by modifying epigenetic marks. The gene is related to Psc and was orginally identified due to its ability to suppress transvection at z.