Enables tyrosine 3-monooxygenase activity. Involved in several processes, including cellular response to amphetamine; dopamine biosynthetic process from tyrosine; and male mating behavior. Located in axon. Expressed in dopaminergic neurons; socket cell; and in male. Used to study several diseases, including amphetamine abuse; cocaine abuse; and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; artery disease (multiple); and obesity. Is an ortholog of human TH (tyrosine hydroxylase).
Enriched in AWBL and neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by smn-1 and cat-2 based on RNA-seq studies. Is predicted to encode a protein with the following domains: PAN-3 domain and PAN-like domain.