akt-2

Caenorhabditis elegans

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3).

akt-1

Caenorhabditis elegans

Enables calmodulin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; regulation of synaptic assembly at neuromuscular junction; and signal transduction. Located in axon; cytoplasmic side of plasma membrane; and somatodendritic compartment. Expressed in several structures, including excretory canal; neurons; pharynx; rectal gland cell; and ventral nerve cord. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3).

pptr-1

Caenorhabditis elegans

Enables protein kinase binding activity and protein phosphatase activator activity. Contributes to protein serine/threonine phosphatase activity. Involved in several processes, including P granule assembly; determination of adult lifespan; and negative regulation of insulin receptor signaling pathway. Located in cytosol. Expressed in head; spermatheca; tail; and vulva. Used to study cancer. Is an ortholog of human PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon).

ist-1

Caenorhabditis elegans

Predicted to enable insulin receptor binding activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in dauer larval development; insulin receptor signaling pathway; and short-term memory.

eak-3

Caenorhabditis elegans

Expressed in XXXL and XXXR.

rict-1

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activator activity. Involved in mesendoderm development. Part of TORC2 complex. Expressed in several structures, including head neurons; intestine; pharynx; spermatheca; and ventral nerve cord. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of human RICTOR (RPTOR independent companion of MTOR complex 2).

W04B5.5

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Is an ortholog of human PDPK1 (3-phosphoinositide dependent protein kinase 1) and PDPK2P (3-phosphoinositide dependent protein kinase 2, pseudogene).

eak-4

Caenorhabditis elegans

Involved in dauer larval development. Located in plasma membrane. Expressed in XXXL and XXXR.

eak-6

Caenorhabditis elegans

Predicted to enable protein tyrosine phosphatase activity. Involved in dauer larval development. Located in plasma membrane. Expressed in XXXL and XXXR.

pdk-1

Caenorhabditis elegans

Enables protein kinase activity. Involved in several processes, including cellular response to reactive oxygen species; dauer larval development; and regulation of synaptic assembly at neuromuscular junction. Located in axon; neuronal cell body; and nucleus. Expressed in several structures, including gonad; intestine; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Is an ortholog of human PDPK1 (3-phosphoinositide dependent protein kinase 1).