Mir708

Mus musculus

PHENOTYPE: Mice homozygous for a null allele suppresses Apc^Min-induced tumorigenesis. [provided by MGI curators]

Rab5c

Homo sapiens

Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

Zfp82

Mus musculus

PHENOTYPE: Mice heterozygous for a null allele exhibit increased colon tumor in Apc^Min. Mice homozygous for a conditional allele activated in the colon exhibit increased sensitivity to AOM/DSS-induced tumors. [provided by MGI curators]

ckb-2

Caenorhabditis elegans

Enables choline kinase activity. Involved in CDP-choline pathway and IRE1-mediated unfolded protein response. Predicted to be located in cytoplasm. Expressed in head and tail. Human ortholog(s) of this gene implicated in several diseases, including colon adenoma; megaconial type congenital muscular dystrophy; narcolepsy; and recurrent hypersomnia. Is an ortholog of human CHKA (choline kinase alpha) and CHKB (choline kinase beta).

Sptssa

Homo sapiens

Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]

Khsrp

Homo sapiens

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

Mir10a

Mus musculus

PHENOTYPE: Mice homozygous for a targeted deletion are viable with no observed pathologies. Mice homozygous for a knock-out allele exhibit increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas in Apc^min heterozygotes. [provided by MGI curators]

Sptssb

Homo sapiens

Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]