sem-2

Caenorhabditis elegans

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; positive regulation of developmental process; and positive regulation of egg-laying behavior. Located in nucleus. Expressed in several structures, including E lineage cell; M.v nucleus; RMH; body wall muscle cell from M lineage; and neuroblasts. Human ortholog(s) of this gene implicated in several diseases, including Coffin-Siris syndrome (multiple); hypotrichosis-lymphedema-telangiectasia syndrome; and hypotrichosis-lymphedema-telangiectasia-renal defect syndrome. Is an ortholog of several human genes including SOX11 (SRY-box transcription factor 11); SOX18 (SRY-box transcription factor 18); and SOX4 (SRY-box transcription factor 4).