sun-1

Caenorhabditis elegans

Predicted to enable protein-membrane adaptor activity. Involved in several processes, including centrosome localization; embryo development; and regulation of centrosome duplication. Located in nuclear envelope. Expressed in several structures, including Caa; Psub4; Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Is an ortholog of human SUN5 (Sad1 and UNC84 domain containing 5).

B0272.4

Caenorhabditis elegans

Predicted to enable delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be located in peroxisome. Expressed widely. Is an ortholog of several human genes including CDY1 (chromodomain Y-linked 1); CDY2A (chromodomain Y-linked 2A); and CDYL (chromodomain Y like).

npr-12

Caenorhabditis elegans

Predicted to enable neuropeptide Y receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Expressed in FLPL; FLPR; PVDL; and PVDR. Human ortholog(s) of this gene implicated in several diseases, including amphetamine abuse; cocaine abuse; and heroin dependence. Is an ortholog of human NPY1R (neuropeptide Y receptor Y1); NPY4R (neuropeptide Y receptor Y4); and NPY4R2 (neuropeptide Y receptor Y4-2).

suco-1

Caenorhabditis elegans

Predicted to be located in cytoplasm and membrane. Expressed widely. Is an ortholog of human SUCO (SUN domain containing ossification factor).

kdp-1

Caenorhabditis elegans

Located in cytoplasm and nuclear envelope. Used to study muscular dystrophy.

cyy-1

Caenorhabditis elegans

Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Involved in negative regulation of synapse assembly; regulation of neuron remodeling; and regulation of terminal button organization. Located in axon and dendrite. Is an ortholog of human CCNY (cyclin Y) and CCNYL1 (cyclin Y like 1).

unc-84

Caenorhabditis elegans

Enables lamin binding activity. Involved in several processes, including egg-laying behavior; nuclear migration along microtubule; and vulval development. Located in nuclear inner membrane. Expressed in several structures, including oocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Is an ortholog of human SUN2 (Sad1 and UNC84 domain containing 2) and SUN3 (Sad1 and UNC84 domain containing 3).

cey-4

Caenorhabditis elegans

Enables ribonucleoprotein complex binding activity. Predicted to be involved in regulation of gene expression. Part of ribonucleoprotein complex. Expressed in germ cell; germ line; and somatic cell. Is an ortholog of human YBX1 (Y-box binding protein 1) and YBX2 (Y-box binding protein 2).

npr-8

Caenorhabditis elegans

Predicted to enable neuropeptide Y receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in plasma membrane.

his-70

Caenorhabditis elegans

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in nucleus. Predicted to be part of nucleosome. Expressed in sperm. Is an ortholog of human H3Y1 (H3.Y histone 1) and H3Y2 (H3.Y histone 2).