sun-1

Caenorhabditis elegans

Predicted to enable protein-membrane adaptor activity. Involved in several processes, including centrosome localization; embryo development; and regulation of centrosome duplication. Located in nuclear envelope. Expressed in several structures, including Caa; Psub4; Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Is an ortholog of human SUN5 (Sad1 and UNC84 domain containing 5).

suco-1

Caenorhabditis elegans

Predicted to be located in cytoplasm and membrane. Expressed widely. Is an ortholog of human SUCO (SUN domain containing ossification factor).

kdp-1

Caenorhabditis elegans

Located in cytoplasm and nuclear envelope. Used to study muscular dystrophy.

Y67A10A.7

Caenorhabditis elegans

Predicted to be located in mitochondrion. Is an ortholog of several human genes including ARMCX1 (armadillo repeat containing X-linked 1); ARMCX2 (armadillo repeat containing X-linked 2); and ARMCX3 (armadillo repeat containing X-linked 3).

unc-84

Caenorhabditis elegans

Enables lamin binding activity. Involved in several processes, including egg-laying behavior; nuclear migration along microtubule; and vulval development. Located in nuclear inner membrane. Expressed in several structures, including oocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Is an ortholog of human SUN2 (Sad1 and UNC84 domain containing 2) and SUN3 (Sad1 and UNC84 domain containing 3).

him-7

Caenorhabditis elegans

nsun-5

Caenorhabditis elegans

Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in several processes, including negative regulation of cellular response to heat; negative regulation of locomotion involved in locomotory behavior; and positive regulation of rRNA processing. Predicted to be located in nucleolus. Used to study Williams-Beuren syndrome. Is an ortholog of human NSUN5 (NOP2/Sun RNA methyltransferase 5).

him-2

Caenorhabditis elegans

F38E9.1

Caenorhabditis elegans

Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Is an ortholog of human PLCXD2 (phosphatidylinositol specific phospholipase C X domain containing 2) and PLCXD3 (phosphatidylinositol specific phospholipase C X domain containing 3).

nsun-2

Caenorhabditis elegans

Enables tRNA (cytidine-5-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Is an ortholog of human NSUN2 (NOP2/Sun RNA methyltransferase 2).