- gei-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Human ortholog(s) of this gene implicated in colorectal cancer. Is an ortholog of human DLC1 (DLC1 Rho GTPase activating protein); STARD13 (StAR related lipid transfer domain containing 13); and STARD8 (StAR related lipid transfer domain containing 8).
- C06H2.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable lipid binding activity. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 2. Is an ortholog of human STARD7 (StAR related lipid transfer domain containing 7).
- strl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable lipid binding activity. Predicted to be involved in vesicle tethering to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum membrane; endoplasmic reticulum-endosome membrane contact site; and late endosome membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Is an ortholog of human STAR (steroidogenic acute regulatory protein).
- tag-340 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable lipid binding activity. Predicted to be involved in vesicle tethering to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum membrane; endoplasmic reticulum-endosome membrane contact site; and late endosome membrane. Is an ortholog of human STARD3 (StAR related lipid transfer domain containing 3).
- Stard6 [Search on AGR]
Rattus norvegicus Predicted to enable lipid binding activity. Orthologous to human STARD6 (StAR related lipid transfer domain containing 6); INTERACTS WITH (+)-pilocarpine; 2,2',5,5'-tetrachlorobiphenyl; acetamide.
- Stard6 [Search on AGR]
Homo sapiens Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
- mts [Search on AGR]
Drosophila melanogaster microtubule star (mts) encodes the catalytic subunit of protein phosphatase 2A. It is involved in various developmental processes and signaling pathways, such as Hh signaling and Wingless signaling.