ceh-12

Caenorhabditis elegans

Predicted to enable sequence-specific double-stranded DNA binding activity. Involved in negative regulation of gene expression and neuron fate specification. Predicted to be located in nucleus. Expressed in VB neuron; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in Currarino syndrome. Is an ortholog of human MNX1 (motor neuron and pancreas homeobox 1).

F39E9.7

Caenorhabditis elegans

Enriched in several structures, including GLR; VB neuron; XXX cell; head mesodermal cell; and intestine based on microarray; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including mut-2; htz-1; and atfs-1 based on microarray; tiling array; and RNA-seq studies. Is affected by eight chemicals including rotenone; Psoralens; and allantoin based on RNA-seq and microarray studies.

efl-3

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Expressed in VA neuron; VB neuron; head neurons; and ventral nerve cord. Is an ortholog of human E2F8 (E2F transcription factor 8).

hum-2

Caenorhabditis elegans

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be located in several cellular components, including actin cytoskeleton; cytoplasm; and vesicle. Predicted to be part of myosin complex. Expressed in DB1. Used to study Griscelli syndrome type 1. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1; microvillus inclusion disease; and progressive familial intrahepatic cholestasis. Is an ortholog of human MYO5A (myosin VA); MYO5B (myosin VB); and MYO5C (myosin VC).

F58B3.6

Caenorhabditis elegans

Enriched in several structures, including AFD; CEPsoVL; VB neuron; dopaminergic neurons; and germ line based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; etr-1; and rsks-1 based on microarray; RNA-seq; and proteomic studies. Is affected by nine chemicals including Zidovudine; Psoralens; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Armadillo-type fold; Interferon-related developmental regulator, N-terminal; Interferon-related protein conserved region; Interferon-related developmental regulator, C-terminal; Interferon-related developmental regulator; Interferon-related developmental regulator (IFRD); and Phosphorylation site. Is an ortholog of human IFRD2 (interferon related developmental regulator 2). Human IFRD2 enables ribosome binding activity and translation repressor activity.

COX5A

Saccharomyces cerevisiae

Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication

COX5B

Saccharomyces cerevisiae

Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication

cox-5B

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Involved in determination of adult lifespan; lipid storage; and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial envelope. Predicted to be part of mitochondrial respiratory chain complex IV. Is an ortholog of human COX5B (cytochrome c oxidase subunit 5B).

del-1

Caenorhabditis elegans

Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in plasma membrane. Expressed in PVD; cholinergic neurons; motor neurons; and in male. Human ortholog(s) of this gene implicated in bronchiectasis (multiple) and renal tubular transport disease (multiple). Is an ortholog of human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma).

COX5B

Homo sapiens

Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]