sws-1

Caenorhabditis elegans

Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of Shu complex. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis and spermatogenic failure. Is an ortholog of human ZSWIM7 (zinc finger SWIM-type containing 7).

SHU2

Saccharomyces cerevisiae

Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; important for both mitotic and meiotic homologous recombination, and contains a conserved SWIM domain that is necessary for both

sop-3

Caenorhabditis elegans

Predicted to be located in nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and neurons.

meg-4

Caenorhabditis elegans

Involved in P granule assembly; germ cell proliferation; and organelle localization. Located in P granule. Expressed in pharynx.

CSM2

Saccharomyces cerevisiae

Subunit of the Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p anti-recombinase function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis

PSY3

Saccharomyces cerevisiae

Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C

set-1

Caenorhabditis elegans

Predicted to enable RNA binding activity and histone H4K20 methyltransferase activity. Involved in embryo development. Located in nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Is an ortholog of human KMT5A (lysine methyltransferase 5A).

oef-1

Caenorhabditis elegans

Expressed in P lineage cell; germ cell; and oocyte.

R107.2

Caenorhabditis elegans

Predicted to enable ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in metabolite repair. Is an ortholog of human NAXD (NAD(P)HX dehydratase).

Y62E10A.24

Caenorhabditis elegans

Predicted to enable nucleic acid binding activity and ribonuclease P activity. Predicted to be involved in tRNA processing. Predicted to be located in nucleus. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Is an ortholog of human POP7 (POP7 homolog, ribonuclease P/MRP subunit).