ril-2

Caenorhabditis elegans

Predicted to be involved in lysosome organization and regulation of intracellular pH. Predicted to be located in lysosome.

tag-77

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm. Expressed in hermaphrodite gonad and somatic gonad precursor. Is an ortholog of human FGD5 (FYVE, RhoGEF and PH domain containing 5) and FGD6 (FYVE, RhoGEF and PH domain containing 6).

Y37D8A.25

Caenorhabditis elegans

Enriched in AFD; MSpaaapa; germ line; intestine; and oocyte based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including etr-1; hpl-2; and pptr-1 based on tiling array; RNA-seq; and microarray studies. Is affected by four chemicals including hydrogen sulfide; Zidovudine; and rifampin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Pleckstrin homology domain; PH domain; and PH-like domain superfamily. Is an ortholog of human PHETA1 (PH domain containing endocytic trafficking adaptor 1); PHETA2 (PH domain containing endocytic trafficking adaptor 2); and PLEKHJ1 (pleckstrin homology domain containing J1). Human PHETA1 enables protein homodimerization activity.

K10B4.3

Caenorhabditis elegans

Predicted to enable phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in plasma membrane. Is an ortholog of human VEPH1 (ventricular zone expressed PH domain containing 1).

frm-5.2

Caenorhabditis elegans

Enriched in OLL; PVD; head mesodermal cell; oocyte; and sensory neurons based on microarray and RNA-seq studies. Is affected by several genes including cyc-1; etr-1; and mrps-5 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by eleven chemicals including metformin; Sirolimus; and silicon dioxide nanoparticle based on RNA-seq; microarray; and proteomic studies. Is predicted to encode a protein with the following domains: PDZ domain; FERM/acyl-CoA-binding protein superfamily; FERM N-terminal domain; Band 4.1 domain; FERM C-terminal PH-like domain; FERM, C-terminal PH-like domain; FERM, N-terminal; FERM superfamily, second domain; Non-receptor Tyrosine-protein Phosphatases; Ubiquitin-like domain superfamily; PDZ superfamily; FERM central domain; and PH-like domain superfamily. Is an ortholog of human FRMPD2 (FERM and PDZ domain containing 2). Human FRMPD2 enables 1-phosphatidylinositol binding activity.

acd-1

Caenorhabditis elegans

Predicted to enable ligand-gated sodium channel activity. Involved in response to acidic pH and sodium ion transport. Predicted to be located in plasma membrane. Expressed in AMshL and AMshR. Is an ortholog of human ASIC4 (acid sensing ion channel subunit family member 4).

F31D4.5

Caenorhabditis elegans

Enriched in several structures, including accessory cell; intestine; neurons; oocyte; and tail hypodermis based on RNA-seq; tiling array; and single-cell RNA-seq studies. Is affected by several genes including nuo-6; atfs-1; and etr-1 based on microarray and RNA-seq studies. Is affected by nineteen chemicals including 1-methylnicotinamide; methylmercuric chloride; and rotenone based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Pleckstrin homology domain; PH domain; and PH-like domain superfamily. Is an ortholog of human PLEKHD1 (pleckstrin homology and coiled-coil domain containing D1).

exc-5

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in cell morphogenesis; epithelial cell development; and regulation of tube size. Located in several cellular components, including actin cytoskeleton; apical cortex; and cell body. Expressed in excretory cell; hermaphrodite gonad; neurons; pharyngeal muscle cell; and rectal epithelium. Used to study Charcot-Marie-Tooth disease type 4H and X-linked Aarskog syndrome. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4H; X-linked Aarskog syndrome; and invasive ductal carcinoma. Is an ortholog of several human genes including FGD1 (FYVE, RhoGEF and PH domain containing 1); FGD3 (FYVE, RhoGEF and PH domain containing 3); and FGD4 (FYVE, RhoGEF and PH domain containing 4).

F23H11.4

Caenorhabditis elegans

Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm. Expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Is an ortholog of human ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3).

CJA33805

Caenorhabditis japonica

Is predicted to encode a protein with the following domains: PH-BEACH domain and PH domain associated with Beige/BEACH.