rad-54.L

Caenorhabditis elegans

Enables ATP-dependent activity, acting on DNA. Predicted to be involved in double-strand break repair via synthesis-dependent strand annealing and reciprocal meiotic recombination. Located in nucleus. Human ortholog(s) of this gene implicated in breast cancer; non-Hodgkin lymphoma; and pancreatic cancer. Is an ortholog of human RAD54L (RAD54 like).

Ap5z1

Homo sapiens

This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]

ipla-2

Caenorhabditis elegans

Predicted to enable actin filament binding activity. Involved in intestinal lipid catabolic process and response to starvation. Located in cytoplasm. Expressed in body wall musculature; head neurons; intestine; and seam cell.

Hr

Rattus norvegicus

Enables histone deacetylase binding activity; nuclear receptor binding activity; and transcription corepressor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Part of histone deacetylase complex. Used to study focal segmental glomerulosclerosis and proteinuria. Human ortholog(s) of this gene implicated in alopecia; alopecia universalis; and atrichia with papular lesions. Orthologous to human HR (HR lysine demethylase and nuclear receptor corepressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

ISC10

Saccharomyces cerevisiae

Meiosis-specific MAPK inhibitor; binds Smk1p during meiosis I; links APC/C-Ama1 to Smk1p activation; required for sporulation; transcript is induced 7.5 hr after induction of meiosis; Isc10p is ubiquitylated and degraded in an Ama1p-dependent manner upon completion of meiosis II

brc-2

Caenorhabditis elegans

Enables single-stranded DNA binding activity. Involved in several processes, including DNA metabolic process; egg-laying behavior; and embryo development. Located in condensed nuclear chromosome.