Ncmap

Rattus norvegicus

A structural constituent of myelin sheath. Involved in peripheral nervous system myelin formation and positive regulation of myelination. Located in Schmidt-Lanterman incisure and paranode region of axon. Orthologous to human NCMAP (non-compact myelin associated protein); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene.

mal

Rattus norvegicus

A structural constituent of myelin sheath. Involved in myelination. Located in Schmidt-Lanterman incisure. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human MAL (mal, T cell differentiation protein); INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Ncmap

Homo sapiens

Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Predicted to be integral component of plasma membrane. Predicted to be active in Schmidt-Lanterman incisure and paranode region of axon. [provided by Alliance of Genome Resources, Apr 2022]

Cldn5

Rattus norvegicus

Predicted to enable identical protein binding activity. Involved in myelination and response to ethanol. Located in Schmidt-Lanterman incisure; lateral plasma membrane; and paranode region of axon. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CLDN5 (claudin 5); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Marveld2

Rattus norvegicus

Predicted to be involved in bicellular tight junction assembly and establishment of endothelial barrier. Predicted to act upstream of or within cell-cell junction organization and sensory perception of sound. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and tight junction. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 49. Orthologous to human MARVELD2 (MARVEL domain containing 2); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; alpha-Zearalanol.

Myoc

Rattus norvegicus

Predicted to enable fibronectin binding activity; myosin light chain binding activity; and signaling receptor binding activity. Involved in cellular response to nerve growth factor stimulus and nerve development. Located in Schmidt-Lanterman incisure; mesaxon; and myelin sheath abaxonal region. Biomarker of membranoproliferative glomerulonephritis and ocular hypertension. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.

Jam3

Rattus norvegicus

Predicted to enable cell-cell adhesion mediator activity; identical protein binding activity; and integrin binding activity. Involved in axon regeneration. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Predicted to be part of filamentous actin and protein complex involved in cell adhesion. Predicted to be active in cell-cell contact zone and plasma membrane. Biomarker of sciatic neuropathy. Orthologous to human JAM3 (junctional adhesion molecule 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

mag

Rattus norvegicus

Enables carboxylic acid binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of neuron differentiation; and regulation of neurogenesis. Located in several cellular components, including Schmidt-Lanterman incisure; mesaxon; and myelin sheath adaxonal region. Used to study middle cerebral artery infarction and sciatic neuropathy. Biomarker of nerve compression syndrome. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 75. Orthologous to human MAG (myelin associated glycoprotein); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Sirt2

Rattus norvegicus

Enables NAD-dependent protein lysine deacetylase activity and tubulin deacetylase activity. Involved in several processes, including myelination in peripheral nervous system; regulation of nervous system development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Part of heterochromatin. Is active in glutamatergic synapse. Used to study high grade glioma and metabolic dysfunction-associated steatotic liver disease. Biomarker of cocaine dependence and intermittent claudication. Orthologous to human SIRT2 (sirtuin 2); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol.

Akr1b1

Rattus norvegicus

Enables aldose reductase (NADPH) activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including cellular response to peptide; inner medullary collecting duct development; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B); PARTICIPATES IN polyol pathway; altered galactose metabolic pathway; D-glycericacidemia pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.