gfl-1

Caenorhabditis elegans

Predicted to enable chromatin binding activity and histone binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Is an ortholog of human YEATS4 (YEATS domain containing 4).

znf653

Homo sapiens

Enables AF-2 domain binding activity and transcription corepressor activity. Involved in extracellular negative regulation of signal transduction and negative regulation of nucleic acid-templated transcription. Predicted to be located in extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

plc-1

Caenorhabditis elegans

Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Expressed in excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome type 2; and nephrotic syndrome type 3. Is an ortholog of human PLCE1 (phospholipase C epsilon 1).

Raph1

Rattus norvegicus

Predicted to be involved in signal transduction. Predicted to act upstream of or within axon extension. Predicted to be located in cell leading edge and nuclear body. Predicted to be active in cytosol and plasma membrane. Orthologous to human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Zfp653

Rattus norvegicus

Predicted to enable AF-2 domain binding activity; DNA-binding transcription factor binding activity; and transcription corepressor activity. Predicted to be involved in extracellular negative regulation of signal transduction and negative regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Predicted to be active in nucleus. Orthologous to human ZNF653 (zinc finger protein 653); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

mig-10

Caenorhabditis elegans

Enables SH3 domain binding activity. Involved in several processes, including cell migration; cell projection organization; and egg-laying behavior. Located in neuronal cell body membrane; plasma membrane bounded cell projection; and presynaptic cytosol. Part of filamentous actin. Expressed in hermaphrodite gonad; neurons; and tail. Is an ortholog of human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1).

Esrrg

Rattus norvegicus

Predicted to enable several functions, including AF-2 domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and estrogen response element binding activity. Predicted to be involved in nuclear receptor-mediated steroid hormone signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. Orthologous to human ESRRG (estrogen related receptor gamma); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Ppargc1b

Rattus norvegicus

Predicted to enable AF-2 domain binding activity; nuclear estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in response to cAMP; response to glucocorticoid; and response to nutrient. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta); INTERACTS WITH (R)-lipoic acid; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Heyl

Rattus norvegicus

Predicted to enable several functions, including AF-1 domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and protein homodimerization activity. Predicted to be involved in several processes, including heart development; nephron development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation; negative regulation of gene expression; and skeletal muscle cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human HEYL (hes related family bHLH transcription factor with YRPW motif like); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Ift122

Homo sapiens

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]