dpm-1

Caenorhabditis elegans

Predicted to enable dolichyl-phosphate beta-D-mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; and protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Is an ortholog of human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic).

ADNP-AS1

Homo sapiens

ASSOCIATED WITH congenital disorder of glycosylation; congenital disorder of glycosylation Ie; genetic disease; INTERACTS WITH sodium arsenite; sotorasib; trametinib

hum-1

Caenorhabditis elegans

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be located in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Is an ortholog of human MYO1E (myosin IE).

Myo1e

Rattus norvegicus

Predicted to enable several functions, including ATP hydrolysis activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in several processes, including actin filament organization; glomerular filtration; and glomerulus development. Predicted to act upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; post-embryonic hemopoiesis; and vasculogenesis. Located in cuticular plate. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Dnmt1

Homo sapiens

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Dpm1

Rattus norvegicus

Enables D-mannose binding activity; alcohol binding activity; and dolichyl-phosphate beta-D-mannosyltransferase activity. Involved in GDP-mannose metabolic process and dolichol metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic); PARTICIPATES IN N-linked glycan biosynthetic pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; aconitine.

Dpm1

Homo sapiens

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Myo1c

Homo sapiens

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]