salt

Drosophila melanogaster

salty dog (salt) encodes a sodium/solute symporter in the SLC5 family involved in response to salt stress.

Atp8b1

Mus musculus

PHENOTYPE: Homozygous mice display abnormal bile salt homeostasis, normal bile secretion, and an impaired ability to handle increased bile salt loading resulting in liver damage and weight loss on a bile salt supplemented diet. [provided by MGI curators]

casy-1

Caenorhabditis elegans

Predicted to enable calcium ion binding activity. Involved in several processes, including GABAergic synaptic transmission; olfactory learning; and positive regulation of synaptic vesicle transport. Located in several cellular components, including extracellular region; neuromuscular junction; and neuronal cell body membrane. Expressed in neurons. Is an ortholog of human CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3).

gcy-5

Caenorhabditis elegans

Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in chemosensory behavior; chemotaxis; and response to salt. Located in cilium. Expressed in ASER; amphid neurons; head neurons; and nervous system.

gcy-6

Caenorhabditis elegans

Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in several processes, including positive regulation of calcium-mediated signaling; response to magnesium ion; and response to salt. Predicted to be located in plasma membrane. Expressed in ASEL.

tmc-1

Caenorhabditis elegans

Enables sodium channel activity. Involved in detection of stimulus involved in sensory perception; monoatomic ion transmembrane transport; and sensory perception of chemical stimulus. Located in neuronal cell body; non-motile cilium; and plasma membrane. Expressed in body wall musculature; neurons; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Is an ortholog of human TMC3 (transmembrane channel like 3).

gcy-4

Caenorhabditis elegans

Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in chemosensory behavior; chemotaxis; and response to salt. Predicted to be located in plasma membrane. Expressed in ASER.

ENA1

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance

ppk11

Drosophila melanogaster

pickpocket 11 (ppk11) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family. In the larval stage, it is expressed in the terminal organ for salt taste and tracheal cells for liquid clearance. It functions in salt taste in adult flies.

Nedd4l

Mus musculus

PHENOTYPE: Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis. [provided by MGI curators]