OVOC10343

Onchocerca volvulus

Is predicted to encode a protein with the following domains: Kank N-terminal motif and KN motif.

Kank3

Rattus norvegicus

Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human KANK3 (KN motif and ankyrin repeat domains 3); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.

kn

Drosophila melanogaster

knot (kn) encodes a transcription factor required for somatic and alary muscle specification and embryonic head segmentation. In larvae, it is required for wing disc patterning and plays a key role in the lymph gland, both under normal conditions and under immune stress.

Kank4

Rattus norvegicus

Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human KANK4 (KN motif and ankyrin repeat domains 4); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

SRAE_X000036000

Strongyloides ratti

Is predicted to encode a protein with the following domains: Ankyrin repeat; Kank N-terminal motif; Domain of unknown function DUF3447; KN motif; Ankyrin repeat-containing domain superfamily; and Ankyrin repeats (3 copies). Is an ortholog of C. elegans vab-19. In C. elegans, vab-19 is involved in several processes, including actin cytoskeleton organization; cell-cell junction maintenance; and embryo development.

TMUE_1000004101

Trichuris muris

Is predicted to encode a protein with the following domains: Ankyrin repeat; Ankyrin repeats (many copies); Kank N-terminal motif; Domain of unknown function DUF3447; KN motif; Ankyrin repeat-containing domain superfamily; and Ankyrin repeats (3 copies). Is an ortholog of C. elegans vab-19. In C. elegans, vab-19 is involved in several processes, including actin cytoskeleton organization; cell-cell junction maintenance; and embryo development.

Kank2

Homo sapiens

This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]

Kank2

Rattus norvegicus

Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; podocyte cell migration; and regulation of intracellular signal transduction. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

vab-19

Caenorhabditis elegans

Involved in several processes, including actin cytoskeleton organization; cell-cell junction maintenance; and embryo development. Located in cell-cell junction; hemidesmosome; and intermediate filament. Expressed in hypodermis; marginal cell; uterus; and vulD. Used to study cancer. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16; renal cell carcinoma; and spastic quadriplegic cerebral palsy 2. Is an ortholog of human KANK2 (KN motif and ankyrin repeat domains 2).

Kank1

Rattus norvegicus

Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including negative regulation of cellular component organization; negative regulation of substrate adhesion-dependent cell spreading; and regulation of signal transduction. Predicted to be located in nucleus and ruffle membrane. Predicted to be active in cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 2. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.