male fertility factor kl3 (kl-3) encodes a dynein heavy chain that is a component of a microtubule motor complex. This motor activity is essential only for spermatogenesis. Lack of kl-3 results in loss of the axonemal out dynein arms in the spermatid tail.
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Is an ortholog of human UBR3 (ubiquitin protein ligase E3 component n-recognin 3).
PHENOTYPE: Mice homozygous for an ENU induced allele that segregates with Kl<sup>m1Btlr</sup> exhibit short tibia, femur, and pelvis. [provided by MGI curators]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway.
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway.
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway.
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway. Is an ortholog of C. elegans F10G7.10.
Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Expressed in hypodermis and intestine. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including congenital lactase deficiency; end stage renal disease; and intracranial embolism. Is an ortholog of human GBA3 (glucosylceramidase beta 3 (gene/pseudogene)) and LCTL (lactase like).
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway. Is an ortholog of C. elegans F10G7.10.
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway. Is an ortholog of C. elegans F10G7.10.