uwl

Mus musculus

PHENOTYPE: Homozygotes for this spontaneous mutation exhibit pigmentation abnormalities. The coat, ears, tail and skin are lighter in color and eyes are unpigmented at birth and become ruby with age. [provided by MGI curators]

rb

Drosophila melanogaster

ruby (rb) encodes the beta3-adaptin subunit of the Adaptor protein-3 (AP-3) complex involved in biogenesis of lysosome-related organelles. It is required for regulation of lipid storage, eye pigment biogenesis and the processing of the receptor encoded by N.