mr

Drosophila melanogaster

morula (mr) encodes the APC2 subunit of the anaphase promoting complex (APC). mr strong alleles produce lethality, metaphase arrest and neuroblast polyploidy. mr weak alleles result in female sterility, affecting the endocycle in the nurse cells, as well as metaphase arrest in early embryonic mitoses.

lmgA

Drosophila melanogaster

lemming A (lmgA) encodes the RING-finger containing Apc11 subunit of the APC/C ubiquitin ligase (E3). Together with the cullin subunit encoded by mr, it forms the minimal ubiquitin ligase module of the APC/C.

Cfap65

Homo sapiens

The protein encoded by this gene has putative coiled-coil domains and may be a transmembrane protein. The chicken ortholog of this gene is involved in the Rose-comb mutation, which is a large chromosome inversion, resulting in altered comb morphology and defects in sperm motility. [provided by RefSeq, Aug 2016]