paic-1

Caenorhabditis elegans

Enables identical protein binding activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).

adss-1

Caenorhabditis elegans

Predicted to enable adenylosuccinate synthase activity. Predicted to be involved in 'de novo' AMP biosynthetic process and IMP metabolic process. Predicted to be located in cytoplasm. Is an ortholog of human ADSS1 (adenylosuccinate synthase 1).

tdo-2

Caenorhabditis elegans

Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Is an ortholog of human TDO2 (tryptophan 2,3-dioxygenase).

PPA39683

Pristionchus pacificus

Is predicted to encode a protein with the following domains: De-etiolated protein 1, Det1 and De-etiolated protein 1 Det1.

haao-1

Caenorhabditis elegans

Predicted to enable 3-hydroxyanthranilate 3,4-dioxygenase activity. Predicted to be involved in 'de novo' NAD biosynthetic process from tryptophan and quinolinate metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human HAAO (3-hydroxyanthranilate 3,4-dioxygenase).

dhod-1

Caenorhabditis elegans

Predicted to enable dihydroorotate dehydrogenase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleotide biosynthetic process. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Is an ortholog of human DHODH (dihydroorotate dehydrogenase (quinone)).

smc-3

Caenorhabditis elegans

Predicted to enable double-stranded DNA binding activity. Predicted to be involved in mitotic sister chromatid cohesion. Part of chromatin and cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Is an ortholog of human SMC3 (structural maintenance of chromosomes 3).

atic-1

Caenorhabditis elegans

Predicted to enable IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Is an ortholog of human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase).

Bm12912

Brugia malayi

Is predicted to encode a protein with the following domains: De-etiolated protein 1, Det1 and De-etiolated protein 1 Det1. Is an ortholog of O. volvulus OVOC833.

OVOC833

Onchocerca volvulus

Is predicted to encode a protein with the following domains: De-etiolated protein 1, Det1 and De-etiolated protein 1 Det1. Is an ortholog of B. malayi Bm12912.