C4a

Rattus norvegicus

Predicted to enable complement component C1q complex binding activity. Predicted to be involved in complement activation and positive regulation of apoptotic cell clearance. Located in extracellular space. Human ortholog(s) of this gene implicated in Graves' disease; complement component 4a deficiency; renal cell carcinoma; systemic lupus erythematosus; and vitiligo. Orthologous to several human genes including C4A (complement C4A (Chido/Rodgers blood group)); PARTICIPATES IN classical complement pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

C4b

Rattus norvegicus

Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Predicted to be involved in complement activation and positive regulation of apoptotic cell clearance. Predicted to act upstream of or within immunoglobulin mediated immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to several human genes including C4B (complement C4B (Chido/Rodgers blood group)); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.