Cavin4

Homo sapiens

This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]

mrck-1

Caenorhabditis elegans

Enables myosin light chain kinase activity. Involved in several processes, including embryonic body morphogenesis; positive regulation of endocytic recycling; and regulation of Golgi organization. Located in cytoplasm. Expressed in Ea and Ep. Used to study cerebral cavernous malformation. Is an ortholog of human CDC42BPA (CDC42 binding protein kinase alpha) and CDC42BPB (CDC42 binding protein kinase beta).

Limk2

Homo sapiens

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]