- eco-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable peptide-lysine-N-acetyltransferase activity. Predicted to be involved in mitotic sister chromatid cohesion. Predicted to be located in nucleus. Predicted to be part of chromatin. Human ortholog(s) of this gene implicated in Roberts syndrome; lung adenocarcinoma; and rheumatoid arthritis. Is an ortholog of human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2).
- Esco2 [Search on AGR]
Homo sapiens This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. [provided by RefSeq, Jul 2008]
- Piezo2 [Search on AGR]
Homo sapiens The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
- Ltw6 [Search on AGR]
Mus musculus PHENOTYPE: One of many loci showing variation in liver cytosol polypeptides detected by high resolution 2D electrophoresis. Allele a is present in most strains; allele b is found in strains SWR/J, BUB, PL, and MA/My. [provided by MGI curators]
- ECO1 [Search on AGR]
Saccharomyces cerevisiae Acetyltransferase required for sister chromatid cohesion; elicits cohesin dimerization during S phase; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by Cdc28p, Cdc7p, Mck1p to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; relative distribution to nucleus increases upon DNA replication stress; mutations in human homolog ESCO2 cause Roberts syndrome
- Gpt [Search on AGR]
Mus musculus PHENOTYPE: Electrophoretic variants are detected in C57BL/6, BALB/c and DBA/2 (a allele); in MA/J and NZB/Bl (b allele). M. m. molossinus and M. m. castaneus have either the b or c allele. In liver, GPT1 activity rises dramatically at 12-19 days to adult levels. [provided by MGI curators]
- Ly11 [Search on AGR]
Mus musculus PHENOTYPE: This locus controls an antigen on T-cell subpopulations. The a allele determines absence of Ly11.2 antigen in A/J, BALB/c, C3H/DiSn, CE, NZB, CBA/J and SWR. The b allele determines antigen presence in C57 strains, AKR, C58, DBA/2, SJL, 129, PL and MA/My. [provided by MGI curators]
- Reln [Search on AGR]
Rattus norvegicus Predicted to enable very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; response to glucocorticoid; and response to progesterone. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypothyroidism and status epilepticus. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin); PARTICIPATES IN Reelin signaling pathway; altered Reelin signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
- Ly9 [Search on AGR]
Mus musculus PHENOTYPE: This locus controls an antigen on thymocytes, lymphocytes and bone marrow cells. The a allele determines Ly9.1 antigen in A/J, 129/Re, BALB/c and C3H/He; the b allele determines antigen Ly9.2 in the C57 family of strains, HTI/Go, MA/My, F/St and C58/Lw. Null mutants are viable, healthy and fertile. [provided by MGI curators]
- Klrb1c [Search on AGR]
Mus musculus PHENOTYPE: This locus controls an antigen on natural killer cells. The a allele determines the Nk1.1 antigen in strains CE, C57BL/6, C57BR/cd, C57L, C58, DBA/1, MA/My, NZB, SJL, SM and B10.D2. The b allele determines the Nk1.2 antigen in strains CBA/J, BALB/c, C3H/He, A/J, DBA/2, LP and 129. [provided by MGI curators]