lt [Search on AGR]
Drosophila melanogaster light (lt) encodes a cellular-protein trafficking protein that forms part of the homotypic fusion and vacuolar protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET) complexes. It is required for fusion of autophagosomes with lysosomes, endocytic down-regulation of Notch signaling, and eye pigment biogenesis.
mt-Nd2 [Search on AGR]
Mus musculus PHENOTYPE: A single point mutation specific to the ALR/Lt strain confers increased resistance to autoimmune diabetes. A conplastic strain generated with ALR nuclear DNA and NOD mtDNA exhibits increased mitochondrial ROS production relative to either parental strain, NOD.mt<sup>ALR</sup> or C57BL/6 controls. [provided by MGI curators]
Vps11 [Search on AGR]
Drosophila melanogaster Vacuolar protein sorting 11 (Vps11) encodes a Class C Vps core subunit of HOPS, a heterohexameric tethering complex that consists of the products of car, dor, lt, Vps11, Vps16A and Vps39. HOPS tethers autophagosomes or late endosomes with lysosomes to facilitate fusion. The product of Vps11 roles include autophagosome-lysosome fusion, late endosome-lysosome fusion and biosynthetic trafficking to lysosomes.
Hma [Search on AGR]
Mus musculus PHENOTYPE: This locus controls HPRT electrophoretic variation in erythrocytes. The dominant a allele is seen in A/J, DBA/2J and CBA/J; the b allele in C57BL/6J, SJL/J and LT/Sv. Strain distribution is the same as Hbb alleles d and s, suggesting HPRT mobility variation may be an effect of HBB chain difference. [provided by MGI curators]