- irk-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inward rectifier potassium channel activity. Involved in short-term memory. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in HSNL; HSNR; and sensory neurons. Human ortholog(s) of this gene implicated in several diseases, including Bartter disease type 2; EAST syndrome; and Leber congenital amaurosis 16. Is an ortholog of human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10); KCNJ13 (potassium inwardly rectifying channel subfamily J member 13); and KCNJ15 (potassium inwardly rectifying channel subfamily J member 15).
- irk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables inward rectifier potassium channel activity. Involved in regulation of G protein-coupled receptor signaling pathway and regulation of egg-laying behavior. Located in neuron projection and neuronal cell body. Expressed in egg-laying apparatus; gonad; intestine; and neurons. Human ortholog(s) of this gene implicated in several diseases, including glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Is an ortholog of several human genes including KCNJ2 (potassium inwardly rectifying channel subfamily J member 2); KCNJ3 (potassium inwardly rectifying channel subfamily J member 3); and KCNJ4 (potassium inwardly rectifying channel subfamily J member 4).
- irk-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in intestine; pharyngeal-intestinal valve cell; spermatheca; and uterus. Human ortholog(s) of this gene implicated in several diseases, including glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Is an ortholog of several human genes including KCNJ2 (potassium inwardly rectifying channel subfamily J member 2); KCNJ4 (potassium inwardly rectifying channel subfamily J member 4); and KCNJ5 (potassium inwardly rectifying channel subfamily J member 5).