C29E4.10

Caenorhabditis elegans

Predicted to enable galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Krabbe disease; and Mycoplasma pneumoniae pneumonia. Is an ortholog of human GALC (galactosylceramidase).

F35A5.1

Caenorhabditis elegans

Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in intermediate filament bundle assembly. Predicted to be located in neurofilament. Human ortholog(s) of this gene implicated in several diseases, including Creutzfeldt-Jakob disease; autoimmune disease of the nervous system (multiple); and neuropathy (multiple). Is an ortholog of human NEFH (neurofilament heavy chain).

Snora16b

Rattus norvegicus

ASSOCIATED WITH Creutzfeldt-Jakob disease (ortholog); INTERACTS WITH 2-hydroxypropanoic acid (ortholog); cadmium dichloride (ortholog); rac-lactic acid (ortholog)

Snora16b

Homo sapiens

INVOLVED IN RNA processing (inferred); ASSOCIATED WITH Creutzfeldt-Jakob disease; FOUND IN nucleolus (inferred); INTERACTS WITH 2-hydroxypropanoic acid; cadmium dichloride; rac-lactic acid

unc-64

Caenorhabditis elegans

Enables protein-folding chaperone binding activity. Involved in several processes, including chemical synaptic transmission; positive regulation of anterior/posterior axon guidance; and ventral cord development. Located in axon; basolateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including excretory gland cell; hermaphrodite gonad; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including Creutzfeldt-Jakob disease; Hirschsprung's disease; and generalized epilepsy with febrile seizures plus 9. Is an ortholog of human STX1A (syntaxin 1A).

Prnp

Rattus norvegicus

Enables several functions, including ATP-dependent protein binding activity; lamin binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; and response to copper ion. Located in postsynaptic density. Used to study hyperglycemia and scrapie. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein (Kanno blood group)); PARTICIPATES IN glypican signaling pathway; iron uptake pathway; prion disease pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Prnp

Homo sapiens

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Stx1a

Rattus norvegicus

Enables several functions, including ATP-dependent protein binding activity; calcium-dependent protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; positive regulation of secretion by cell; and synaptic vesicle exocytosis. Located in several cellular components, including actomyosin; postsynaptic density; and secretory granule. Part of several cellular components, including synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; synaptic membrane; and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.