- Frem3 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null allele exhibit no embryonic lethality and normal fertility, size, and no apparent Fraser syndrome- or MOTA/BNAR-like developmental defects. [provided by MGI curators]
- Fras1 [Search on AGR]
Rattus norvegicus Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; metanephros morphogenesis; and roof of mouth development. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
- Frem2 [Search on AGR]
Rattus norvegicus Predicted to be involved in anatomical structure morphogenesis and cell adhesion. Predicted to act upstream of or within several processes, including embryonic digit morphogenesis; eye development; and inner ear development. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Used to study Fraser syndrome 2. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
- Frem2 [Search on AGR]
Homo sapiens This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
- Grip1 [Search on AGR]
Rattus norvegicus Enables GTPase binding activity; PDZ domain binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and positive regulation of cell projection organization. Located in several cellular components, including dendrite; spine synapse; and synaptic membrane. Part of exocyst. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in Fraser syndrome 3. Orthologous to human GRIP1 (glutamate receptor interacting protein 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline.