- JP [Search on AGR]
Drosophila melanogaster junctophilin (jp) belongs to a gene family encoding proteins anchored to the endoplasmic reticulum through a transmembrane region. The product of jp contributes to the formation and maintenance of junctional membrane complexes. It serves as a physical bridge between the plasma membrane and the endoplasmic reticulum in excitable cells, allowing the functional crosstalk between ion channels. It is necessary for calcium signalling in muscle contraction and neuronal communication.
- Ythdf2 [Search on AGR]
Rattus norvegicus Predicted to enable C5-methylcytidine-containing RNA reader activity; N6-methyladenosine-containing RNA reader activity; and mRNA binding activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; regulation of gene expression; and regulation of stem cell differentiation. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic ribonucleoprotein granule; and cytosol. Predicted to be active in cytoplasm. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein F2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
- Ythdc1 [Search on AGR]
Rattus norvegicus Enables N6-methyladenosine-containing RNA reader activity. Involved in mRNA splicing, via spliceosome. Located in nuclear body. Orthologous to human YTHDC1 (YTH N6-methyladenosine RNA binding protein C1); INTERACTS WITH 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione; ammonium chloride.
- Stk38 [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including ATP binding activity; UFM1-modified protein reader activity; and magnesium ion binding activity. Involved in postsynapse organization. Is active in glutamatergic synapse. Orthologous to human STK38 (serine/threonine kinase 38); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
- Ankrd13b [Search on AGR]
Rattus norvegicus Predicted to enable ubiquitin-modified protein reader activity. Predicted to be involved in negative regulation of receptor internalization. Predicted to be located in endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ANKRD13B (ankyrin repeat domain 13B); INTERACTS WITH (+)-schisandrin B; furan; tetrachloromethane.
- Ccdc38 [Search on AGR]
Rattus norvegicus Predicted to enable ubiquitin-modified histone reader activity. Predicted to be involved in acrosome assembly. Predicted to be located in several cellular components, including manchette; sperm flagellum; and sperm head. Predicted to be active in centrosome. Orthologous to human CCDC38 (coiled-coil domain containing 38); INTERACTS WITH (+)-schisandrin B; bisphenol A; cadmium dichloride.
- Rbm33 [Search on AGR]
Rattus norvegicus Predicted to enable N6-methyladenosine-containing RNA reader activity and lncRNA binding activity. Predicted to be involved in RNA export from nucleus and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human RBM33 (RNA binding motif protein 33); INTERACTS WITH 17beta-estradiol; acetamide; alpha-Zearalanol.
- Ankrd13d [Search on AGR]
Rattus norvegicus Predicted to enable ubiquitin-modified protein reader activity. Predicted to be involved in negative regulation of receptor internalization. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ANKRD13D (ankyrin repeat domain 13D); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
- TOP3 [Search on AGR]
Drosophila melanogaster Topoisomerase 3beta (Top3beta) encodes an RNA topoisomerase that participates in both transcription and translation. It promotes transcription by being recruited by the product of Tdrd3, an epigenetic reader recognizing dimethylarginine motifs in core histones. It contributes to translation by complexing with the product of Fmr1, an RNA-binding protein deficient in fragile X mental retardation syndrome.
- Ddrgk1 [Search on AGR]
Rattus norvegicus Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; UFM1-modified protein reader activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DDRGK1 (DDRGK domain containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; leflunomide.