Enables identical protein binding activity. Predicted to be involved in protein refolding and response to heat. Located in cytoplasm. Expressed in hypodermis; intestine; muscle cell; and spermatid. Human ortholog(s) of this gene implicated in cataract (multiple); dilated cardiomyopathy 1II; and myofibrillar myopathy (multiple). Is an ortholog of human CRYAA (crystallin alpha A); CRYAB (crystallin alpha B); and HSPB6 (heat shock protein family B (small) member 6).
Enables ATP hydrolysis activity. Involved in determination of adult lifespan; response to heat; and retrograde transport, endosome to Golgi. Located in cytosol and nucleus. Expressed in germ line and intestine. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); brain disease (multiple); and eye disease (multiple). Is an ortholog of human HSPA8 (heat shock protein family A (Hsp70) member 8).
Is affected by several genes including etr-1; hsp-6; and mrps-5 based on microarray and RNA-seq studies. Is affected by resveratrol based on microarray studies.
Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in mitochondrial unfolded protein response. Located in mitochondrion. Expressed in muscle cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; autosomal dominant sideroblastic anemia 4; and rheumatoid arthritis. Is an ortholog of human HSPA9 (heat shock protein family A (Hsp70) member 9).
Is affected by several genes including hsp-6; rrf-3; and ogt-1 based on microarray and RNA-seq studies. Is affected by paraquat based on RNA-seq studies.
Predicted to enable unfolded protein binding activity. Involved in endoplasmic reticulum unfolded protein response. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A).