Enables carboxylesterase activity. Involved in cellular catabolic process. Located in peroxisome. Expressed in pharynx. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1).
Involved in several processes, including negative regulation of BMP signaling pathway; negative regulation of DNA endoreduplication; and positive regulation of growth rate. Located in adherens junction and plasma membrane. Expressed in head; hypodermis; intestinal cell; intestine; and tail.
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is an ortholog of human PRDM14 (PR/SET domain 14).
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of distal tip cell migration; regulation of developmental process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Expressed in several structures, including distal tip cell; dorsal nerve cord; enteric muscle; neurons; and tail hypodermis. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung adenocarcinoma; and non-Hodgkin lymphoma (multiple). Is an ortholog of human PRDM1 (PR/SET domain 1).
Enables DNA-binding transcription factor activity. Involved in several processes, including regulation of developmental process; regulation of mitotic cell cycle; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including MSaaap; MSpaap; gonad; neurons; and somatic gonad precursor. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1LL and myeloid neoplasm. Is an ortholog of human MECOM (MDS1 and EVI1 complex locus) and PRDM16 (PR/SET domain 16).
Enables histone H3K4 methyltransferase activity. Predicted to be involved in chromatin remodeling and methylation. Predicted to be located in nucleus. Expressed in several structures, including body wall musculature; excretory cell; intestine; primary spermatocyte; and vulval muscle. Is an ortholog of human PRDM7 (PR/SET domain 7).