- Rnl27 [Search on AGR]
Mus musculus PHENOTYPE: Mice with this mutation exhibit elevated blood urea nitrogen (BUN; 47 mg/dl). [provided by MGI curators]
- cact [Search on AGR]
Drosophila melanogaster cactus (cact) encodes the homolog of mammalian IkappaB. cact product acts as an inhibitor of NF-kappaB signaling by binding to the products of dl and Dif, which prevents their nuclear translocation. Toll signaling promotes the destruction of cact protein, which allows the products of dl and Dif to enter the nucleus and regulate gene expression.
- dbr [Search on AGR]
Drosophila melanogaster debra (dbr) encodes a transcriptional coactivator of various transcription factors, including the products of ci and dl. It contributes to developmental patterning, long-term memory, and cellular proliferation.
- tamo [Search on AGR]
Drosophila melanogaster tamo (tamo) encodes a protein with an essential function during oogenesis where it interacts with the product of dl and proteins that are part of the nuclear import machinery.
- dl [Search on AGR]
Drosophila melanogaster dorsal (dl) encodes a transcription factor that functions with the product of Dif, downstream of the Toll pathway. It contributes to certain functions of the Toll pathway, notably the dorsoventral patterning of early embryo.
- GPP1 [Search on AGR]
Saccharomyces cerevisiae Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; GPP1 has a paralog, GPP2, that arose from the whole genome duplication
- GPP2 [Search on AGR]
Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication
- PolE4 [Search on AGR]
Drosophila melanogaster DNA polymerase epsilon subunit 4 (PolE4) encodes an accessory, non-catalytic subunit of the major replicative polymerase epsilon. It is one of the maternal target genes of the transcription factor encoded by dl and is regulated by the DRE/DREF pathway.
- Akr1a1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased osteoporosis in response to pregnancy or castration in the absence of dietary ascorbate. Mice homozygous for a knock-out allele exhibit reduced asorbic acid levels and DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity. [provided by MGI curators]